Pacecil,
At the risk of being accused of adding to the supply of anecdotal somethingortheother (Actually, I forget...oblique reference to another thread.) Let me relate a story.
My first quasi bench rifle was a 722 that was in an old single shot 40x rimfire stock, that had had the bedding device cut off and the accessory rail slot filled in. It had a HV contour Hart barrel that started out 24" long. The chamber had a .244 neck, and it liked 53 gr Sierras, 205s, and, of all things,748. The chamber was designed around a one piece FL die, but most of the time I used custom fitted Wilson dies. I loaded at the range, Shot off a home made front rest, and used 6' 1x2s with surveyor's tape to try to read the wind. It was a steady performer in the area of 1/4 - 5/16 at 100 yd.
One afternoon, with mild temperatures and wind, I was shooting groups that were all touching and all of a sudden I had paper between. Surprised, i started looking for an explanation. Coindidentally I happeded to have taken a concentricity gauge (given to me by a friend) with me that day. Being familiar with the usual reading, I was surprised to find that the last few rounds from the small batch that I had just loaded were not to the usual standard. I figured that something was wrong with one of my dies. Upon inspection I found a particle of ball powder stuck to the inside of the seater, about half way down the body cavity. I removed it; the rounds went back to their previous readings, and all of the shots went back to touching. That was good enough for me. Now ask me if I can tell the difference between the 6PPC rounds that are .0015 or less out of my seater, and those that I have straightened to half of that......Heck if I know, but straighter makes me more confident, and confidence counts.
Once, when I took a new gauge to a match and was busily straightening as I loaded, I had several friends come other to check their ammo, and one fellow repeatedly exclaim that he didn't care what his measured, and wasn't going to check them. (Methinks he doth protest too much...(Wlm. who?))
Now about that runout...for factory chambers and unturned necks I have heard reports, and personally found that if you neck size with a Collet die and then use a body die with a slight bump, you will get the most consistently straight ammunition (measured on the bullet). Try it, you might like it, and do it in that order; it matters.
I have worked a lot on this problem, both for factory and a competition rifle. If money were no object, i would order a set of FL reamers, matching my chamber reamer, with a selection of neck diameters, and stick with one piece dies. These have given me the most consistently small runout. Whether the difference matters is another matter. Below a certain point, I don't know.
BTW I appreciate you telling us about your shooting history. Many of your posts have seemed to be about theory, so I didn't have a way to judge your "on the ground" experience, which, as you have explained, is considerable.