Find your bullet first.
I believe that barrels and bullets are the primary determinants of an accurate load. Since it is much easier and cheaper to change bullets than barrels, we let the rifle choose the bullet. I choose my favorite bullet and hope the rifle likes it. If it doesn't, I'll switch to my alternate bullet and start again.
Pick a powder.
If you look at several handloading manuals, you will notice that there are usually a couple of powders that stand out from the others in a particular bullet weight. You can also use recommendations from other handloaders on sites such as this, but don't be shy about taking internet advice with a grain of salt. There are a lot of people on the internet who are absolute idiots, and many actually know less than you. That won't keep them from giving you advice. For the most part, you can rely on companies that have invested a lot of time and money testing many combinations of components for a load. If a bullet manufacturer states that two certain powders were the most accurate in their testing, you can usually take their word for it, at least with the same components they used for their testing. If your bullet doesn't like that powder, try your alternate powder and start over.
Seat bullets out as far as you can, initially.
For a hunting rifle, I usually seat my bullets as far out as the magazine will allow. Once I have found my load, I can incrementally seat the bullet a little deeper to fine tune the load.
Use the ladder method to work up your load and find the sweet spot.
Changing primers is the very last thing I try if I'm not happy with a load. I usually use Federal Match primers. They are very consistent. Consistency and accuracy are very closely related.
Practice, practice, practice.
Just my humble opinion, and worth exactly what you paid for it.